Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence.
نویسندگان
چکیده
By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 4 شماره
صفحات -
تاریخ انتشار 2004